Development prospects of acidifierHite [1411] Publish time :2017-08-10
With the increase of feed prices, the cost of pig farming is rising, and the nutrition management of young piglets is paid more and more attention because the formula culture of weaning plays a decisive role in its follow-up performance and is the key to the market benefit. Achieving good long-term and optimal feed efficiency of piglets at this stage is the core requirement for the success of today's animal production systems. The use of acidifiers in piglets and finishing pigs at all ages is widely considered to be an effective way to achieve these objectives, as evidenced by research institutes and farmland trials. The mechanism of action of organic acids and their salts is also described in detail in a large number of literatures. Organic acid salts and complex preparations as feed preservatives and technical additives in the world are approved for use.
1, acidifier alternative antibiotic demand increased
Although antibiotics as a growth agent has brought great economic benefits to pig production, but the strain of drug resistance problems are increasingly found, coupled with the application of antibiotics in livestock and poultry meat residues , Will bring great health to human health. Today, long-term use of sub-therapeutic doses of antibiotics in healthy animal feed is not appropriate, both in terms of nutrition and veterinary epidemiology. So the world's consumers and management of the disabled or limit the use of antibiotics, enjoy the safety of green food is growing. The EU has decided that the first four kinds of antibiotic growth promoters currently in use will be phased out from 1 January 2006. To find a substitute for antibiotics, but also to maintain the role of antibiotics to promote the growth of safe alternatives, as the current feed industry, one of the hot spots. Among them, organic acids, especially organic acid salts, have aroused widespread interest in nutrition and pig farming, poultry and aquaculture. Frost & Sullivian, a global growth consulting firm, published a report in 2004, "Prohibited the use of antibiotics to promote the growth of raw materials to bring great opportunities for feed acidifier," said that by 2009, the entire European animal feed acidifier output value from 2002 l The 9.1 billion euros to 400 million euros, the increase will be more than 2 times over the past seven years more.
2, acidification agent physiological function
Acidifier is to improve the feed acidity, through the combination with the feed or water, animal consumption, can improve its digestive tract environment to meet the nutritional needs and disease prevention needs. Its efficacy for animal nutrition and feed preserving has been known for 50 years and has been confirmed in a large number of scientific studies. Inorganic acid has a strong acidity and relatively low cost of addition, but in the course of the process will destroy the gastric mucosal function and even burn the gastric mucosa, inhibition of gastric acid secretion and piglet stomach normal development, can not play a role in the posterior intestinal The And macromolecules organic acids such as citric acid, lactic acid, fumaric acid, etc., in reducing the pH and feed acid binding strength than organic small molecules is low, so the effect of organic small molecules than inorganic and macromolecular organic acid is better. For example, formic acid in the organic acid of the smallest molecular weight (organic acid per unit weight of acid to a carbonic acid acid strongest), but the bactericidal effect is better. Acidifier has a lot of functional effects, but not every single acid has both. At the same time, the different effects of a single organic acid are largely dependent on the degree of dissociation. Each acid has its fixed dissociation constant expressed in pK (buffering capacity), that is, the pH at 50% dissociation in the solution, The effect of the acid under the condition of pH. Higher buffering capacity avoids excessive fluctuations in gastrointestinal acidity in animals. Such as at a certain pH without early dissociation or less dissociation, or promote the reduction of PH, you can continue to play an antibacterial effect. The reduction in feed pH on the one hand leads to a smaller buffer capacity and, on the other hand, promotes the digestion of animals because the stomach does not need to secrete more endogenous hydrochloric acid to activate the protease, thereby ensuring a perfect digestive protein. As mentioned earlier, a stable digestive mechanism means that the gastrointestinal microbial flora is balanced. The reduction of pH also provides an obstacle to the propagation of harmful bacteria, thereby indirectly achieving antimicrobial effects. Therefore, the effectiveness of the organic acid depends largely on the buffering capacity of the acid in the un-dissociated state to penetrate the cell walls of Gram (negative) negative bacteria (such as E. coli, Salmonella) and penetrate into the cells to play a role. The organic acid dissociates into a hydrogen cation and an acid anion in the cell. Cationic also reduces intracellular pH, and anions disintegrate DNA synthesis in the nucleus. Cell-cell pH reconstruction, so the original energy loss of the cells is re-adjusted for correction. This dual mechanism of action effectively prevents the pathogen proliferation and reproduction.
Formic acid as the smallest molecular weight of organic acids, the pathogen Gram-negative bacteria has the strongest effect. However, due to its corrosive (easy to corrode feed and troughs, drinking water equipment, etc.) and the strong odor of the shortcomings, high-dose addition will reduce the palatability of feed or lead to vitamin loss, greatly limiting its direct application in animal husbandry. Many applications at home and abroad experiments show that potassium formate as a simple molecular compound salt (with a special structure of formic acid and potassium formate), both inherited the anti-mildew effect of formic acid, but also with non-corrosive slow release effect (single acidification Agent release too fast, in the stomach that is fully absorbed, can not play a role in the small intestine parts). Biological source launched a series of acidifier products, with the promotion of pig growth, improve piglets gastrointestinal digestion environment, adjust the palatability of feed, improve animal feed intake, effectively inhibit the feed mold and other harmful ingredients, keep fresh feed Degree and quality, to extend the shelf life of feed and a series of roles.